High MHC and peptide diversities necessitate efficient computational modelling to enable whole proteome structural analysis. 3D structures of pMHC complexes provide fundamental insight into T-cell recognition mechanism and aids immunotherapy design. T-cells are activated when they recognize foreign peptides that are presented on the cell surface by Major Histocompatibility Complexes (MHC), forming peptide:MHC (pMHC) complexes. 5Bijvoet Centre for Biomolecular Research, Faculty of Science - Chemistry, Utrecht University, Utrecht, Netherlandsĭeeper understanding of T-cell-mediated adaptive immune responses is important for the design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks.4Natural Sciences and Engineering section, Netherlands eScience Center, Amsterdam, Netherlands.3Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.2Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
0 kommentar(er)
